Thursday, August 27, 2020

Example Answers to Questions on LVMH

Model Answers to Questions on LVMH LVMH is known as worldwide goliath who is celebrated for its extravagance item. The organization is situated in Paris France, with quality of in excess of fifty 6,000 workers from all pieces of the world, the complete number of representatives incorporate only the 33 percent from France. The establishment of organization was set down with 50 extravagance marks in the year 1987, presently the association is decentralized and they are developed and going through various phases of association assessment and accomplishing various milestones in their business. All the fundamental workplaces and head quarter of the organization is at the capital city of France, yet the association can be called as multi culture since they remember people for the higher administration and staff from various foundations, societies and nations. Structure and Operations of LVMH LVMH is a gathering of fifty unique organizations who have around 450 auxiliaries in various areas round the globe; each organization has its own specific manner of doing their business with their leader and the procedure through which they have set up what auxiliary will answer to whom. The administration of LVMH has isolated diverse business activities into five zones internationally; following are the five zones of LVMH business France America Europe Asia Pacific and Japan To accomplish the business principles and improved hierarchical quality the LVMH utilizes various methodologies at various business zones, however the most well-known and most broadly utilized is worldwide portability, they put stock in universal versatility of their higher administration and talented staff, which incorporate vertical and level moves inside the association and geological situation at various business areas and business zones. Working with various social situations is extremely vital for worldwide associations like LVMH, they have to build up their representatives aptitudes and abilities to easily work in multi social condition, however fortunate the greater part of their exiles are globally experienced so this isn't to troublesome undertaking for the higher administration of LVMH to work in multi social condition. Be that as it may, they do give pre flight and post appearance preparing to the entirety of their ostracizes and universal portable staff about the social qualities and other fundamental data which they need to manage during their stay in the nation. Prologue to Task 1 Indentify three key HRM exercises in LVMH and talk about how they fit into by and large corporate destinations of the organization. Contend which model of HRM LVMH conveys and why? Recognizable proof of HRM Activities The three key HRM exercises which I have distinguished from the LVMH contextual analysis are following Enlistment and Selection Profession improvement and International Mobility (T D) Representatives Appraisal System Enlistment and Selection (R S) As LVMH is a worldwide monster with worldwide activity, it is vital for LVMH to have skilled staff to hold their worldwide situation as goliath and give their clients great administrations so as to have a decent name for the association. At start LVMH human asset office was at some point ailing in worldwide experience, contending in a worldwide situation, so LVMH choose to draw in, create and hold administrators with worldwide experience (by 2001 it had 260 exiles and 650 different representatives working in a nation not their own) To accomplish the corporate objectives LVMH is following a complete and sensible methodology for example the LVMH auxiliaries HR chiefs arrange with the business bunches through month to month gatherings, so as to distinguish the empty situations all through the world and furthermore study the rundown of expected up-and-comers inside association who can possibly advance through new task inside the year. After that empty positions are declared on the organization site, so anybody can go after that job around the world, so LVMH draw in experts from everywhere throughout the world for monetary advantages as well as through energizing vocation advancement openings, which help LVMH is getting experts from everywhere throughout the world and accomplish their corporate objectives. Profession Development and International Mobility (T D) From its creation LVMH is a universal association, and to address the issues of a worldwide association, they were deficient in their HR and their global administration abilities. For example in 1987 an excessive number of troughs were not familiar with English so the administration looked to make a group of directors with working information on worldwide market. To have an expertly prepared global class group it is critical to have plans for profession advancement of workers. At LVMH they dont center a lot around formal trainings yet rather than that they incline toward Mobility, portability like vertical, flat and geological moves in association, In request to clean their abilities and get experienced in a universal domain, as once a French protection master in the style specialty unit was sent to Romania to head a shoe manufacturing plant. To have a universal business authority supervisory group LVMH centers around global portability rather than exile, on the grounds that an individual sent from UK to France is bound to return and work in UK with great experience got their in France. The worldwide versatility strategy is a piece of profession advancement which requires the preparation of worldwide troughs on constrained time premise. The HR division persuade a supervisor to turn out to be universally versatile by extending to them all the more testing employment opportunity with more opportunity to play out his assignment than home. One positive part of LVMH universal versatility is to face challenge so as to grow high possibilities. LVMH has two kind of high possibilities HP1 and HP2, a HP1 is an individual going to have top administration position (like leading group of executive) while HP2 is a worker go a stage or higher in the executives chain of command. Representatives Appraisal System Evaluations done appropriately are a fair endeavor to assess someones current execution (for example conduct) and to assist them with distinguishing how to improve. (Nectar, Peter Improve your relationship building abilities, second release, 09) Evaluation is required to perceive ones work and get your representatives inspired and stick on to the hierarchical objectives. The majority of the associations have a deliberate method of examination like once in year, after achievement of an errand. At LVMH execution evaluation framework isn't just founded on results yet additionally to propose and actualize new thoughts. A generally excellent way to deal with evaluate somebody is to assess ones thoughts, since it isn't essential that the top level administration can simply create smart thoughts, recently utilized youthful and lively individuals can deliver thoughts which might be not founded on understanding, however through the most recent and refreshed information and assets they have (like innovation). So LVMH attempt to accomplish their corporate objectives and goals through examination framework. Which HRM Model LVMH conveys LVMH has conveyed the European model of human asset the executives for example Best Fit model. Since in best fit model association recognize HR techniques that fit their business for example showcase, work, size and structure of the association. Legitimization of utilizing Best Fit model At LVMH they have distinctive HR exercises which plainly express what model they have sent in their association. On the off chance that we take the case of International Mobilization the idea driving this is Best Fit as Boxall and Purcell portrayed choices over choice/enlistment, improvement and preparing are vital in nature and must be fit with corporate technique. LVMH is working in various nations managing diverse social individuals, as HR exercises differ from refined individuals, as HR exercises change from social to social, so utilizing the best fit methodology they bargain every nation/auxiliary in the manner which best fit them. At LVMH the HR procedures and business techniques are entomb subordinate, which is as per meaning of (Armstrong, 2003) states that best fit methodology is Inter-reliance between HR systems and business methodologies. Prologue to Task 2 The necessity from this errand is to give data on the key methodologies that how LVMH deals with its representatives preparing and improvement. What are the qualities and shortcomings of their framework and give proposals to LVMH governing body on the best way to improve its system towards TD of its staff the board. Preparing and Development Preparing is the way toward modifying representative conduct and mentalities such that expansion the likelihood of objective achievement [1] or we can characterize preparing as the formal and deliberate adjustment of conduct through realizing which happens because of training, guidance, advancement and arranged experience [2]. Improvement is any learning action which is coordinated toward future needs as opposed to introduce requirements, and which is concerned more with development than prompt execution [2]. How LVMH guarantee their representatives T D To guarantee their representatives expertise improvement and outfitted them with most recent abilities and information on the board LVMH has an assortment of preparing and advancement programs. The fundamental focal point of every one of these exercises is on to set up their workers to address the high market difficulties and to guarantee the accomplishment of their hierarchical objectives and targets through appropriate usage of HR. Following are the key methodologies which LVMH use for their workers preparing and improvement. Universal Mobility Vocation Management (Organizational Management Review OMR) Entomb Cultural preparing Universal Mobility At LVMH worldwide versatility is an action for increasing high vocation achievements, and create administrator to take the worldwide administration positions and empower them to work at a multi social and out of their nations of origin. Worldwide versatility is probably going to involve a radical utilitarian move. Through global portability the administrators are placed into new circumstances to assist them with growing new abilities and demonstrate thei

Saturday, August 22, 2020

Transaction, Operating Accounting Exposures Essay Example Essay Example

Exchange, Operating Accounting Exposures Essay Example Paper Exchange, Operating Accounting Exposures Essay Introduction Exchange, Operating, Accounting (Translation) Exposures Foreign Exchange Exposure †measures the potential for a firm’s benefit, net income, and market an incentive to modify in view of an adjustment in return rates. Q: What are the three primary outside trade exposures? A: 1) Transaction Exposure 2) Operating Exposure 3) Accounting Exposure Transaction Exposure †measures changes in the estimation of remarkable money related commitments brought about before an adjustment in return rates. Working Exposure (Economic Exposure, Competitive Exposure, Strategic Exposure) †measures an adjustment in the current estimation of a firm coming about because of any adjustment in future expected working incomes brought about by startling changes in return rates. Bookkeeping Exposure (Translation Exposure) †measures bookkeeping determined changes in owner’s value because of interpreting remote cash fiscal summaries into a solitary announcing money. Display 8. 1 [pic] Note: In the final quarter of 2001 Amazon. om revealed a total compensation of $5 million, due to some extent to a one-time remote money increase of $16 million. Supporting †To take a place that will rise (or fall) in incentive to balance an adjustment in estimation of a current position. |Benefits of Hedging |Costs of Hedging | |Improved the arranging capacity of the firm. |Risk-opposed system that benefits the executives more than | |Reduced the probability of money related misery. I. e. the hazard that cash|shareholders. (I. e. investors can broaden money hazard on an| |flows will fall beneath what is required for obligation installments and continued|â€Å"as needed† premise) | |operations) |Consumes the firm’s assets and expected incomes to the firm | |Management has a relative bit of leeway over investors. (I. e. |are not expanded. (I. e. gency hypothesis, NPV of supporting is zero, | |understanding the cash danger of the firm and exploit a |and FX misfortu nes show up on the I/S while supporting are covered in | |disequilibrium through particular supporting) |operating and premium costs) | Transaction Exposure Transaction Exposure †measures changes in the estimation of remarkable monetary commitments caused before an adjustment in return rates. Exchange presentation can emerge from the accompanying exercises:? Buying or selling remote products and enterprises using a credit card. Acquiring or loaning in another cash.? Remote trade contracts. Display 8. 3 The Life Span of Transaction Exposure [pic] Example Expect to gather? 1,000,000 out of a quarter of a year on a deal, least adequate worth $1,700,000. Q: What sort of exchange introduction has happened? A: Billing Exposure S0 = $1. 7640/? ES90= $1. 76/? F90= $1. 7540/? iU. K. = 10% every year (2. 5% per quarter) kU. K. = 8% every year (2% per quarter) iU. S. = 8% every year (2% per quarter) kU. S. = 6% every year (1. 5% per quarter) P90ATM = $1. 75 (1. 5% premium) P90OTM = $1. 71 (1% premium) Exchange, Operating Accounting Exposures Essay Body Paragraphs Note: ES90 is the assessed spot rate in a quarter of a year, â€Å"i† is the acquiring loan cost, and â€Å"k† is the venture financing cost, P90ATM is an at-the-cash three-month put alternative, and P90OTM is an out-of-the-cash multi month put choice. Q: Is the pound expected to acknowledge or devalue? A: Depreciate Q: What is the forward premium/markdown on the pound? A: [pic] Q: What are the four choices to fence an exchange presentation? A:1) Remain unhedged 2) Hedge in the forward market 3) Hedge in the currency showcase 4) Hedge in the choices advertise 1) Remain unhedged, gather? 1,000,000 out of a quarter of a year at the new spot rate. pic] 2) Hedge in the forward market, gather? 1,000,000 of every three months at $1. 7540/?. [pic] 3) Hedge in the currency advertise, get? 975,610 today, and trade for dollars at the present spot rate ($1. 7640/? ). Contribute the $1,720,976 for 90 days, and in 90 days repay the advance + enthusiasm with the? 1,000,000. Q: To dev elop a currency showcase fence, what amount should the financial specialist obtain today if the yearly loan fee is 10% and the organization hopes to get? 1,000,000 of every 90 days? A: [pic] Q: At what speculation rate is the currency advertise support better than the forward agreement? A: [pic] pic] Note: Either the forward agreement or the currency advertise support is better than a revealed position if the spot rate at time 2 is not exactly the forward rate. In any case, if the assets can be contributed at anything over 7. 68% (or 1. 92% for 90 days) at that point the currency showcase fence is a superior choice than the forward agreement. On the off chance that the spot rate at time 2 is more prominent than what can be earned by putting the assets in the organization (for this situation the assets are put resources into the organization yielding the company’s WACC of 12% or $1,772,605) at that point the revealed support would be prevalent. 4) Hedge in the choices showcase . An at-the-money[1] (ATM) put alternative is selling for a 1. 5% premium. The expense of the choice is (size of the choice) x (premium) x (spot rate) = cost, for this situation? 1,000,000 x 0. 015 x $1. 7640 = $26,460. This is the most extreme misfortune, while the greatest addition is the spot cost †the expense of the alternative. [pic] To analyze the other options, first gauge what you expect spot rates to be, at that point gauge a scope of potential costs, and think about your capacity to acknowledge the drawback. At that point select the best system. A few Examples: [pic] Q: Transaction introduction emerges from what? A: Sales and costs that are now contracted for. Working Exposure Operating Exposure (Economic Exposure, Competitive Exposure, Strategic Exposure) †measures an adjustment in the current estimation of a firm coming about because of any adjustment in future expected working incomes brought about by sudden changes in return rates. Q: Operating Exposure relie s upon whether a surprising change in return rates causes unforeseen changes in what? A: Sales volume, deals costs, or working costs Figure 9. 1 Financial and Operating Cash Flows Between Parent and Subsidiary [pic] Q: What are four proactive approaches to oversee working introduction? A: 1) Matching money incomes 2) Risk-sharing understandings 3) Back-to-back or resemble credits 4) Currency trades Note: Planning for working presentation relies upon the cooperation of techniques in account, advertising, buying, and creation. Bookkeeping (Translation) Exposure Accounting Exposure (Translation Exposure) †measures bookkeeping determined changes in owner’s value because of deciphering outside cash fiscal summaries into a solitary announcing money. Q: What are the budgetary objectives of the worldwide undertaking? A:1) To amplify united after-charge salary ) To limit the firm’s compelling worldwide taxation rate 3) To address the situating of the firm’s pay, inc omes, and accessible assets. Note: These objectives are much of the time seen as conflicting. Practical cash †the overwhelm money utilized by the remote auxiliary in its everyday tasks. Q: What are the two essential techniques for the interpretation of remote auxiliary budget summaries? A: 1) The present rate strategy 2) The transient technique Current rate strategy †a technique for deciphering the fiscal summaries of outside associates into the parent’s revealing money. All benefits and liabilities are deciphered at the present swapping scale. Fleeting technique †accept that various individual detail resources, for example, stock and net plant and gear are rehashed consistently to reflect advertise esteem. Q: Which strategy is the most widely recognized around the world? A: The present rate strategy Q: What are the upsides of the present rate technique? A: 1) The changeability of revealed profit because of interpretation additions or misfortunes is killed, on the grounds that the increase or misfortune on interpretation goes legitimately to a hold account (as opposed to going through the pay articulation). ) Does not contort monetary record proportions, for example, the present proportion or obligation to-value proportion (in light of the fact that the general extents of the individual asset report accounts continue as before. Q: What is the disservice of the present rate strategy? A: 1) It disregards the bookkeeping guideline of conveying asset report accounts at chronicled costs. Q: What is the upside of the transient strategy? A: 1) Foreign nonmonetary resources are conveyed at their unique expense in the parent’s solidified articulation. Schoolwork Problems Chapter 8 1. Envision one of the organizations from your last task is expecting a $80million installment in one year. The organization additionally anticipates $20million in costs in a single year. Utilize genuine figures or the accompanying: Current spot rate 3. 4x/$ (patt ern shows 3. 8x/$ two months back) Interest rates are 14% in your nation and 4% in the U. S. Forward agreements are excessively costly Based on the present spot rate and relative loan costs, it would be ideal if you prompt your organization on its money introduction. Part 9 2. Envision one of your organizations will before long be sending out to China. Utilize the accompanying (supplant the $ proportional with your cash at the present spot value): Current deals of 1,000,000 units for every year at a value proportionate to $24 each. Current spot value Rmb8. 2/$, however the H. K. warning will drop the incentive one week from now to Rmb10/$. Direct expenses are 75% of the U. S. dollar deals cost. Tolerating this figure, exhort the organization on two alternatives: 1) Maintain the equivalent renminbi value (I. e. no adjustment in value) 2) Raise the cost to counterbalance the downgrading and experience a 10% drop in unit volume. A) What might be the short-run (one year) effect of every technique? B) Which do you suggest? Discretionary Assignment: (0. 5 support focuses) Prepare a review on the nation you are accomplishing for your last undertaking. (Incorporate GDP, expansion, significant fares/imports, significant stock trade, money, conversion scale, and whatever else you find intriguing and applicable). use sources like countryreports.

Friday, August 21, 2020

Research Proposal Writing - Tips For Effective Research Proposal Writing

Research Proposal Writing - Tips For Effective Research Proposal WritingHaving a well-written research proposal is just as important as having a great idea. This document can either help you secure a good job or leave you to a cold reception. Let's look at some tips for writing a research proposal that will help you get your application into the system.Your research proposals are not done for you. To write a good one, you must know what your employer wants, so don't use this as an opportunity to just go off and read 'every new book' on the subject. You'll also need to have enough information to convince them that you are qualified to do the job.First, get a project outline, and follow it to the letter. Use an outline to keep you on track. Don't expect to come up with all of the details on your own, and remember that the research industry is a competitive one. You will need to present your proposal as clearly and coherently as possible, with maximum use of charts and graphs.If you're looking to gain as much experience as possible, ask some of your existing clients to give you some feedback on your research proposal writing. What they would like to see in it? Do they find it thorough?You can make your proposal flow nicely and seamlessly if you can get your proposal down to a high level description of your expertise. Explain exactly what you're capable of doing and why they should hire you.A good research proposal should cover several different types of jobs. If you're applying for a position in a small company, you may be asked to write a proposal on a wide range of topics. If you're doing research for a national government agency, you should be familiar with every aspect of the job.Research proposal writing should be brief and to the point. Each paragraph should be self-contained, without any extraneous information or superfluous data. The format should be one page for a research proposal and two pages for a business plan.Start by making sure that you are very o rganized and have a well thought out outline. Then, start organizing your research, but try to keep it short and punchy. Always include numbers and symbols, so that your proposal writing will not get lost.

Monday, May 25, 2020

Why Did Nietzsche Break With Wagner

Of all the people who Friedrich Nietzsche met, the composer Richard Wagner (1813-1883) was, without question, the one who made the deepest impression on him. As many have pointed out, Wagner was the same age as Nietzsche father, and thus could have offered the young scholar, who was 23 when they first met in 1868, some sort of father substitute. But what really mattered to Nietzsche was that Wagner was a creative genius of the first rank, the kind of individual who, in Nietzsche’s view, justified the world and all its sufferings. Nietzsche and Wagner From an early age Nietzsche was passionately fond of music, and by the time he was a student he was a highly competent pianist who impressed his peers by his ability to improvise.  In the 1860s Wagner’s star was rising. He began receiving the support of King Ludwig II of Bavaria in 1864; Tristan and Isolde had been given its premiere in 1865, The Meistersingers was premiered in 1868, Das Rheingold in 1869, and Die Walkà ¼re in 1870. Although opportunities to see operas performed were limited, both because of location and finances, Nietzsche and his student friends had obtained a piano score of Tristan and were great admirers of what they considered the â€Å"music of the future.† Nietzsche and Wagner became close after Nietzsche began visiting Wagner, his wife Cosima, and their children at Tribschen, a beautiful house beside Lake Lucerne, about a two-hour train ride from Basle where Nietzsche was a professor of classical philology.  In their outlook on life and music, they were both heavily influenced by Schopenhauer.  Schopenhauer viewed life as essentially tragic, stressed the value of the arts in helping human beings cope with the miseries of existence, and accorded pride of place to music as the purest expression of the ceaselessly striving Will that underlay the world of appearances and constituted the inner essence of the world. Wagner had written extensively about music and culture in general, and Nietzsche shared his enthusiasm for trying to revitalize culture through new forms of art. In his first published work, The Birth of Tragedy (1872), Nietzsche argued that Greek tragedy emerged â€Å"out of the spirit of music,† fueled by a dark, irrational â€Å"Dionysian† impulse which, when harnessed by â€Å"Apollonian† principles of order, eventually gave rise to the great tragedies of poets like Aeschylus and Sophocles.  But then the rationalist tendency evident in the plays Euripides, and most of all in the philosophical approach of Socrates, came to dominate, thereby killing the creative impulse behind Greek tragedy. What is now needed, Nietzsche concludes, is a new Dionysian art to combat the dominance of Socratic rationalism. The closing sections of the book identify and praise Wagner as the best hope for this sort of salvation. Needless to say, Richard and Cosima loved the book. At that time Wagner was working to complete his Ring cycle while also trying to raise money to build a new opera house at Bayreuth where his operas could be performed and where whole festivals devoted to his work could be held. While his enthusiasm for Nietzsche and his writings was no doubt sincere, he also saw him as someone who could be useful to him as an advocate for his causes among academics. Nietzsche had, most remarkably, been appointed to a professor’s chair at the age of 24, so having the backing of this apparently rising star would be a notable feather in Wagner’s cap.  Cosima, too, viewed Nietzsche, as she viewed everyone, primarily in terms of how they might help or harm her husband’s mission and reputation But Nietzsche, however much he revered Wagner and his music, and although he had quite possibly fallen in love with Cosima, had ambitions of his own.  Although he was willing to run errands for the Wagners for a time, he became increasingly critical of Wagner’s overbearing egoism. Soon these doubts and criticisms spread to take in Wagner’s ideas, music, and purposes. Wagner was an anti-Semite, nursed grievances against the French which fueled hostility to French culture, and was sympathetic to German nationalism.  In 1873 Nietzsche became friends with Paul Rà ©e, a philosopher of Jewish origin whose thinking was heavily influenced by Darwin, materialistic science, and French essayists like La Rochefoucauld.  Although Rà ©e lacked Nietzsche’s originality, he clearly influenced him.  From this time on, Nietzsche begins to view French philosophy, literature, and music more sympathetically.  Moreover, instead of continuing his critique of Socratic rationalism, he starts to praise the scientific outlook, a shift reinforced by his reading of Friedrich Lange’s History of Materialism. In 1876 the first Bayreuth festival took place.  Wagner was at the center of it, of course. Nietzsche originally intended to participate fully, but by the time the event was underway he found the cult of Wagner, the frenetic social scene swirling around the comings and goings of celebrities, and the shallowness of the surrounding festivities unpalatable.  Pleading ill health, he left the event for a time, returned to hear some performances, but left before the end. That same year Nietzsche published the fourth of his â€Å"Untimely Meditations†, Richard Wagner at Bayreuth.  Although it is, for the most part, enthusiastic, there is a noticeable ambivalence in the author’s attitude toward his subject.  The essay concludes, for instance, by saying that Wagner is â€Å"not the prophet of the future, as perhaps he would wish to appear to us, but the interpreter and clarifier of the past.†Ã‚  Hardly a ringing endorsement of Wagner as the savior of German culture. Later in 1876 Nietzsche and Rà ©e found themselves staying in Sorrento at the same time as the Wagners.  They spent quite a lot of time together, but there is some strain in the relationship.  Wagner warned Nietzsche to be wary of Rà ©e on account of his being Jewish.  He also discussed his next opera, Parsifal, which to Nietzsche’s surprise and disgust was to advance Christian themes. Nietzsche suspected that Wagner was motivated in this by a desire for success and popularity rather than by authentic artistic reasons. Wagner and Nietzsche saw each other for the last time on November 5th, 1876. In the years that followed, they became both personally and philosophically estranged, although his sister Elisabeth remained on friendly terms with the Wagners and their circle. Nietzsche pointedly dedicated his next work, Human, All Too Human, to Voltaire, an icon of French rationalism. He published two more works on Wagner, The Case of Wagner and Nietzsche Contra Wagner, the latter being mainly a collection of previous writings.  He also created a satirical portrait of Wagner in the person of an old sorcerer who appears in Part IV of Thus Spoke Zarathustra.  He never ceased to recognize the originality and greatness of Wagner’s music. But at the same time, he distrusted it for its intoxicating quality, and for its Romantic celebration of death. Ultimately, he came to see Wagner’s music as decadent and nihilistic, functioning as a kind of artistic drug that deadens the pain of existence i nstead of affirming life with all its sufferings.

Thursday, May 14, 2020

Analysis Of The Book The Last Of The Mohicans Essay

American exceptionalism refers to the United States as unique or a different form of democracy from other governments; described as a free nation based on democratic ideals and personal liberties. This term stems from its political, intellectual, and religious, and from its’ enduring exceptional differences. The aftermath of the â€Å"revolution†, freeing the American colonies from British control are key aspects of the belief from where American exceptionalism came about. In addition, Thomas Paine makes clear, of the term in his pamphlet of Common Sense that he wrote anonymously in 1776. In John Winthrop’s A model of Christian Charity of 1630, he goes in-depth with his creation of an instrument of the enlightenment that challenges theocracy. The Last of the Mohicans captures a great visual exploration of how colonist and Indigenous people strived to break away from the British parliament. The set takes place during the French and Indian War (7 years’ war) in 1757. The three most compelling evidences I incorporated; all communicate systems of American exceptionalism. In the pamphlet, Thomas Paine includes his statement on American exceptionalism of the United States, best explaining on the topic of having such a diverse government could make the United States extraordinary compared to other forms of democracies in the world. The writings of Winthrop’s are still-in-effect today, for example, sexual repression and obsessive propriety that goes by the name of â€Å"puritanical†. InShow MoreRelatedReview Of The Last Of The Mohicans 1878 Words   |  8 PagesTayseer Abdelsalam 12/15/16 Early American Literature: Critique #3 The Book vs The Movie The main difference between, The Last of the Mohicans, book by James Fenimore Cooper and the last of the Mohicans movie, is that the book has a more adventurous theme and the moive has a more romantic and love them. I felt that both stories were extremely interesting. Due to the text’s complexityz and the author’s peculiar writing style, it took me quite a while to get into the story, thus reducingRead MoreAnalysis Of The Movie Hawkeye By Robert E. Lee2347 Words   |  10 Pageshis life by how they act and what they say, in general Hawkeye changes pretty drastically throughout the novel. Then I talk about the cultural and historical context of the book. Which include things such as background information about the French and Indian War. My paper also includes a general summary of The Last of the Mohicans, written by James Fenimore Cooper. This summary includes major events, character development, and conflicts in the story. Finally my essay analyzes Hawkeye and his uniquenessRead MoreThe Pioneers: An Analysis of the Character of Natty Bumppo781 Words   |  3 PagesThe Pioneers: An Analysis of the Character of Natty Bumppo The Pioneers is the first in a series of five books by James Fenimore Cooper, though in the time period that the five books covers, it is the fourth, chronologically. The most famous book in this series is The Last of the Mohicans. Together, the five books are known as the Leatherstocking Tales, as they tell the story of Natty Bumppo, who also went by the alias of Leatherstocking. The Pioneers, like the other books in the LeatherstockingRead MoreThe Strawberry Statement Essay924 Words   |  4 PagesDiscusses his lack of authority to write a book, but decides to write one anyway. Discusses that he is the one writing the book, however his thought are no different than the thoughts of the youth of another generation; what you think at nineteen is universal across all generations, youth as a movement has â€Å"always been happening.† (Intro) He wants to do something about racism, poverty, and war. He discusses who they are – kids who have â€Å"hopes and fears†¦ ups and downs.† They’re people in NYC whoRead MoreRacism From Cooper s Book The Last Of The Mohicans 1818 Words   |  8 Pages A reader of The Last of the Mohicans is able to notice the manifested racism in the book which is perpetuated through the cultural divide and racial stereotypes. Racism from Cooper’s book depicts itself in being one of the contemporary themes in the novel which offers derogatory and stereotypical concerns to people of various races. In a more stringent analysis, the racial stereotypic statements from the book drive racial and cultural tolerance along with the societal inequalities which are setRead MoreOrganisational Theory230255 Words   |  922 Pages. Organization Theory Challenges and Perspectives John McAuley, Joanne Duberley and Phil Johnson . This book is, to my knowledge, the most comprehensive and reliable guide to organisational theory currently available. What is needed is a text that will give a good idea of the breadth and complexity of this important subject, and this is precisely what McAuley, Duberley and Johnson have provided. They have done some sterling service in bringing together the very diverse strands of work

Wednesday, May 6, 2020

The M �� Ori Culture - 2199 Words

Most well known civilizations are fairly young in their life spans. The United Kingdom, France, Italy; all these cultures as they are known today have only existed for approximately 400 years. The MÄ ori, an indigenous culture of New Zealand, have existed for a millennia. Specialized in nautical exploits, the MÄ ori thrived off of the island s bountiful seas and developed a unique, rich identity as a people. Yet rather than being regarded as a national treasure, most of New Zealand s citizens and the rest of the world treat the aboriginal population as a novelty. Most top search results for â€Å"MÄ ori Culture† are for attractions, guided tours, and similar spectacles. This culture, which has persisted for nearly a thousand years, is gradually withering into little more than a side show attraction. Rather than scholarly journals, articles, and history text, is instead an encroaching investment of the MÄ ori as capital, and how businesses may benefit from them (Rigby, Mueller, Baker, 2011, 121). This plight of exoticism is not exclusive to the Maori; aboriginal and indigenous societies all over the world are forced into a unique cultural adaption in order to survive in Western capitalist climates. Companies assume a guise of social interest, but â€Å"there is one and only one social responsibility of business - to use its resources and engage in activities designed to increase its profits so long as it stays within the rules of the game† (Rigby, Mueller, Baker, 2011, 118).Show MoreRelatedThe M Ā Ori Culture Essay1327 Words   |  6 PagesRefers to identity; individual cultures; the power an individual gains through their abilities, efforts, taking advantage of all opportunities, and contributing to others. â€Å"In the MÄ ori culture, there are two essential aspects to a person s mana: mana tangata, authority derived from whakapapa connections, and mana huaanga, defined as authority derived from having a wealth of resources to gift to others to bind them into reciprocal obligations.† The concept of Mana tangata indicates the positiveRead MoreNew Zealand s M Ä€ Ori Culture1065 Words   |  5 Pagesâ€Å"New Zealand s MÄ ori culture is an integral part of Kiwi life and adds a unique, dynamic experience for visitors...Find out where to experience  MÄ ori culture by choosing your area of interest in the right-hand menu.† (100% Pure New Zealand). 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Read MoreNotes On Maori Culture And Indian Culture Essay1567 Words   |  7 PagesUnite standard (11647) Tutor Anika Contents Maori culture 3 About the Maori people 3 Maori hui 3 A typical agenda 4 The process and regulations to be followed at a hui 5 Records during hui meetings 5 Etiquette 5 Any regulation and statutory requirements associate with such a meeting 6 New Zealand legislation companies act 1993 6 The basis of meeting 6 Chairperson 7 Notice of meeting 7 Voting 7 Proxies 7 Kiwi culture 7 KIWI culture of business meetings. 7 A typical agenda 8 A process requiredRead MoreUncertainty Of The Business Environment1291 Words   |  6 Pages2. Create the Guiding Coalition 3. Develop a Vision and Strategy 4. Communicate the Change Vision 5. Empower Employees for Broad-Based Action 6. Generate Short-Term Wins 7. Consolidate Gains and Produce More Change 8. Anchor New Approaches in the Culture Planned and emergent are the two main strategies to change management. The planned approach uses the top-down management approach. Top-down management approach starts with the overall business environment and breaks it down into smaller segmentsRead MoreThe Case Of Hiv Vaccine Research : Not A Solely Sin Essay2090 Words   |  9 PagesNot a Solely Sin Introduction A promising vaccine to combat HIV epidemic seems need to wait a lit bit longer since the desired result of HIV vaccine development in Iowa State University (ISU) found to be a fraudulent. Office of Research Integrity (ORI) and ISU found that the Dr. Dong-Pyou Han, former Research Assistant Professor, engaged in research misconduct in this research by intentionally spiked samples of rabbit sera with human antibody. 1-5 It falsified the result that a vaccine developed

Tuesday, May 5, 2020

1901 and Key Features free essay sample

Homework: Writing skills Name: Bui Thi Ha Thu Task 1: The graph and table show the number of fishers in millions for different regions between 1970, 1980 and 2000, and the world’s top ten exporters of fish in 2000. Summarize the information by choosing and reporting the key features, and make any relevant comparisons. The bar graph and the table indicate comparisons of millions of fishers in 5 regions in the world between 1970, 1980 and 2000 and the world’s top ten exporters of fish in 2000.As is illustrated by the bar graph, millions of fishers reveal the most significant amount in Asia while the lowest amount of fishers is showed in Europe throughout three periods of time. The largest amount represents 24 millions of fishers in Asia in 2000 and the least one represents only 0. 3 millions of fishers in Europe in 1970. The level of Asian fishers dramatically rises up whereas the others seem stay the same. While the number of fishers was only 9 millions in 1970 this figure had more than doubled in 2000. We will write a custom essay sample on 1901 and Key Features or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page When others illustrated fluctuations of the total fishers, South America remained unchanged its stability of 1. 2 millions of fishers during three years. Turning to the table of exporters, Thailand stands at the first position among top ten exporters of fish in 2000. Norway and USA also obtain high levels when they occupy the second and the third stands respectively. After these countries, China, Denmark, Canada, Taiwan, Russia, Indonesia follow to take up from the fourth to the ninth levels in turn.South Korea is ranked the tenth position at the bottom of the table. (219 words) Task 2: The two graphs below show the percentage of smokers and the consumption of alcohol in litres in selected countries, for the period 1960-2000. Summarize the information by choosing and reporting the key features, and make any relevant comparisons. The two graphs represent comparisons the percentage of smokers in the population every day in USA, Japan, Holland and alcohol consumption in liters per person among Turkey, Holland and USA from 1960 to 2000.As can be seen from the first graph, 3 countries of the survey indicated a downward trend in percentage of smokers from 1960 to 2000. Holland revealed the highest level while USA stood the lowest percentage of smokers. In 1960, Holland represented 59% of smokers while USA represented 40% and in 2000 Holland showed 32% of smokers while USA indicated 19%. From 1960 to 1970, the percentage of Holland smokers remained unchanged at 59% during which Japan and USA dropped very slightly from 49% to 48% and from 40% to 39% respectively.Holland represented a dramatic change during 1970s when its smoker percentage slumped sharply from 59% to 44% in between 1970 and 1980. From 1980 to 2000, Holland and Japan seemed decline slowly at the same level. The gaps of percentage between Japan and USA seemed stay unchanged about 10-12% from 1960 to 2000. It can be clear from the second graph that 3 countries rose up to the peak of alcohol consumption in 1980. Holland represented the highest level of 11. 3 lirters/person while USA and Turkey represented the second and the third at 10. 1 and 1. 9 lirters/person respectively in 1980.Holland revealed a dominant increase of alcohol consumption while others showed a gradual one from 1960 to 1980. During this time, Holland shot up from 3. 9 litres/person in 1960 to the peak of 11. 3% in 1980. If USA showed the highest level of alcohol consumption in 1960 , Holland prevailed above 3 countries from 1980 at to 2000. Turkey reveals the lowest alcohol consumption when it represented the significant gaps among the others. Especially the graph showed the gaps of 9. 4 litres/person between Turkey and Holland in the pinnacle of 1980. (315 words)

Tuesday, April 7, 2020

Quest For Personal Identity In Toni Morrisons The Bluest Eye Essays

Quest for Personal Identity in Toni Morrison's The Bluest Eye English Quest for Personal Identity in Toni Morrison's The Bluest Eye Post World War I, many new opportunities were given to the growing and expanding group of African Americans living in the North. Almost 500,00 African Americans moved to the northern states between 1910 and 1920. This was the beginning of a continuing migration northward. More than 1,500,000 blacks went north in the 1930's and 2,500,00 in the 1940's. Life in the North was very hard for African Americans. Race riots, limited housing resulting in slum housing, and restricted job opportunities were only a few of the many hardships that the African American people had to face at this time. Families often had to separate, social agencies were overcrowded with people that all needed help, crime rates increased and many other resulting problems ensued. The Bluest Eye by Toni Morrison takes place during this time period. A main theme in this novel is the "quest for individual identity and the influences of the family and c ommunity in that quest" (Trescott). This theme is present throughout the novel and evident in many of the characters. Pecola Breedlove, Cholly Breedlove, and Pauline Breedlove and are all embodiments of this quest for identity, as well as symbols of the quest of many of the Black northern newcomers of that time. The Breedlove family is a group of people under the same roof, a family by name only. Cholly (the father) is a constantly drunk and abusive man. His abusive manner is apparent towards his wife Pauline physically and towards his daughter Pecola sexually. Pauline is a "mammy" to a white family and continues to favor them over her biological family. Pecola is a little black girl with low self esteem. The world has led her to believe that she is ugly and that the epitome of "beautiful" requires blue eyes. Therefore every night she prays that she will wake up with blue eyes. Brought up as a poor unwanted girl, Pecola Breedlove desires the acceptance and love of society. The image of "Shirley Temple beauty" surrounds her. In her mind, if she was to be beautiful, people would finally love and accept her. The idea that blue eyes are a necessity for beauty has been imprinted on Pecola her whole life. "If [I] looked different, beautiful, maybe Cholly would be different, and Mrs. Breedlove too. Maybe they would say, `Why look at pretty eyed Pecola. We mustn't do bad things in front of those pretty [blue] eyes'" (Morrison 46). Many people have helped imprint this ideal of beauty on her. Mr. Yacowbski as a symbol for the rest of society's norm, treats her as if she were invisible. "He does not see her, because for him there is nothing to see. How can a fifty-two-year-old white immigrant storekeeper... see a little black girl?" (Morrison 48). Her classmates also have an effect on her. They seem to think that because she is not beautiful, she is not worth anything except as the focal point of their mockery. "Black e mo. Black e mo. Yadaddsleepsnekked. Black e mo blac k e mo ya dadd sleeps nekked. Black e mo..." (Morrison 65). Shouted by her classmates on such a regular basis, this scorn seemed not to penetrate anymore. As if it were not bad enough being ridiculed by children her own age, adults also had to mock her. Geraldine, a colored woman, who refused to tolerate "niggers", happened to walk in while Pecola was in her house. "`Get out,' she said her voice quiet. `You nasty little black bitch. Get out of my house'" (Morrison 92). By having an adult point out to her that she really was a "nasty" little girl, it seems all the more true. Pecola was never able to get away from this kind of ridicule. At home she was put through the same thing, if not worse because her family members were the ones who were supposed to love her. Her mother was not able conceal her obvious affection towards a white girl over her. One day as Pecola was visiting her mother at the home where she is working, Pecola accidentally knocked over

Monday, March 9, 2020

Ming And Ottoman Empires Essays - Ottoman Turks, Free Essays

Ming And Ottoman Empires Essays - Ottoman Turks, Free Essays Ming And Ottoman Empires Timothy S. Palko World History II Dr. Skaff MWF 2:00-2:50 World power can be seen today in two very different but extremely vast empires. They are the Ming Empire and the Ottoman Empire. To contrast these empires in order to predict their futures, it is necessary that I observe and analyze key factors such as leadership, military strengths and weaknesses, and morals among the people. The two empires have different types of leadership, and from this it is possible to find the core of any disadvantage. From the leadership, it is possible to continue into the military and values that these empires embody. The Ming Empire is led by brilliant philosophical scholars, The man who is promoted to the higher degrees in this field prides himself on the fact that he has in truth attained to the pinnacle of Chinese happiness (Andrea/Overfield 116). The Ottoman Empire has dedicated and knowledgeable leaders as well, but they are of a more warlike and brutish character. These leaders rise in service by merit alone (Andrea/Overfield p.88). Indulging in the writings of Matteo Ricci, who observed first hand the workings of the Ming government, and the writings of Ogier Ghiselin de Busbecq, who observed the government under Suleiman I of the Ottoman Empire, the prediction of success will be able to be made knowledgably. The Ottoman Empire began around 1300 as a tiny state built on the strength of an army of Turkish nomad warriors and a few Christian converts to Islam in northwestern Anatolia (Bulliet 601). It quickly proved to be a military strength and threat to the surrounding civilizations. The Turks expanded their empire through brilliant military tactics, including using Janissaries on foot, who used the new weapon called a gun in battle, and the same horseback archery that made them so successful in their previous military accomplishments. The selection of Turkish leaders has greatly influenced the success of the Ottoman Empire. A Turks grandeur is not defined by his birth, however; the respect to be paid to a man is measured by the position he holds in the public service (Andrea/Overfield 88). The men who attain office are not the products of hereditary luck, but partly the gift of God, and partly the result of good training, great industry, and unwearied zeal (Andrea/Overfield p.88). De Busb ecq was greatly impressed by the way that these Turks found their leadership; he made it a point to describe their feelings towards it in detail. De Busbecq also wrote extensively about the military strengths of the Ottoman. The soldiers of the Ottoman army are well trained and experienced in the arts of warfare and survival. The distances they must travel are so great, that the soldiers often have to carry a pack horse on which they carry many of the necessaries of life (Andrea/Overfield 89). The weapon that was affluent and extremely effective among the soldiers is the Turkish bow. From the eighth, or even the seventh year of age they begin to shoot at a mark, and practice archery ten or twelve years. This constant exercise strengthens the muscles of their arms, and gives them such skill that they can hit the smallest marks with their arrows (Andrea/Overfield p.89). The great riches and skilled military forces have served this Empire well to this day. The Turks also showed very little ignorance towards new advancements in technology originated in other parts of the world. There is no nation that has shown greater readiness t han the Turks to avail themselves of the useful inventions of foreigners, as is proved by their employment of cannons and mortars, and many other things invented by Christians (Andrea/Overfield p.89). These open-minded and innovative new ways of becoming a powerful country greatly impressed De Busbecq. It is true that no empire is without flaw, and the Ottoman is no exception. The role of Sultan in the Ottoman Empire was a hereditary role, the exception to their other laws about leadership. The sons of a Turkish Sultans are in the most wretched position in the world, for, as soon as one of them succeeds his father, the rest are doomed to certain death Andrea/Overfield p.90). The successor will certainly kill all the other sons

Friday, February 21, 2020

Product & pricing (marketing management) Case Study

Product & pricing (marketing management) - Case Study Example TiVo managements, now spearheading a brand new sector of entertainment industry, did a lot on market development which involves marketing existing products, in this case services in new markets. In some degree product development was used but on a limited scale. Perhaps a lot of work on research and development made both market development and diversification attainable. Also in the area of diversification of TiVo services, there were a few brand names to take care of different sets of customers which new market strategy of Ansoff's growth model seeks to explain. More so, 0.04% penetration rate is abysmally low largely due to lack of awareness on the part of customers. A very good indicator, current quarterly subscribers of 14,000, needs to be sustained while means are to be devised through appropriate marketing channels to increase this number in the near future. Concerning product life cycle, one is of the belief that TiVo is still in its introduction stage - infancy probably heading to growth stage. A period of one year or thereabout cannot be safely considered to be in full growth or maturity or have dominating influence on the market. The net loss increasing progressively as shown on exhibit 3 tends to suggest that management must remodel and refocus its strategies in order to remain profitable. Frankly speaking, since the project is still in introduction stage, it will make economic sense if they could focus on TiVo's long-term prospects. Market Attractiveness As said earlier, TiVo has a cutting-edge technology that can impact greatly the entertainment industry if professional inputs are sought on most policy decisions. The market is really vast but the problems TiVo has include inability to relay what it can offer the public and tendency for the very marketers (including columnist) hired to promote the services end up confusing and dispelling customers. Also the model adopted by the co-founders and management are imperfect, this reflects in pricing policy, branding and marketing techniques. TiVo is highly innovative by featuring qualities like pause, fast-forward, rewind, play and record. Conventional TV can not boost of these qualities let alone recording in basic, medium, high and best modes. Important point about this innovative strength is that for TiVo to sell there is need to reach out to customers and let them understand TiVo's value proposition. New Product Development Process New product development process seems to be lacking or non-existent; diversification, an integral component of Ansoff's Growth Matrix requires that products or services be branded (segmented) to satisfy different customers. Differentiating TiVo's service from recording with different prices is one but inadequate service segmentation. Management should think of bundling different services into TiVo like gaming. A close study of customer's preferences for programmes can be another big clue. Brand Positioning Furthermore, TiVo branding has a huge price differential between the two main recording services defeating the whole essence of branding. Charging $499 for a black box for a 14-hour recording and $999 for the same black box and 30 hours of recording is disproportionately high. To make TiVo more attractive, more brands need to be created perhaps to keep competitors at bay even when partnering with

Wednesday, February 5, 2020

The Use of Photography as Historical Evidence Essay

The Use of Photography as Historical Evidence - Essay Example These photographs enhance and elevate the understanding of historians and provide them in-depth information regarding the history and past civilizations and hence, they come up with the enlightening facts regarding the people and societies from the past. The access to important photograph makes possible the sound interpretation and understanding of the historical events and civilizations illuminated by the historian's own knowledge. The historians utilize the photographs conveying a message, specific event, or any facts relevant to historical periods as evidences and proves of the events they point in the course of re-assembling the patches from past life and explicating it to the world. They also use these as evidences to connect or synchronize one historical event or fact to another so as to highlight the causes or significance of an event in the light of a photographed fact and reality. The photographs not only assist the historians in finding out the social events and conditions of the historical era but also elaborate the occupational and work-related situation being confronted by the people of past civilizations.

Tuesday, January 28, 2020

Cell-Permeable Stapled Peptides from HIV1 Gene Products

Cell-Permeable Stapled Peptides from HIV1 Gene Products Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products Introduction HIV-1 Integrase (IN), is necessary enzyme for the replication of the virus into the host cells. It catalyzes the integration of viral DNA into the genome of host cells. The mechanisms employed by the enzyme are strand transfer and 3†²-end processing reactions. The enzyme is vital for the virus life cycle and as a result it is a target for anti-HIV-1 drugs. It is reported from previous studies that HIV-1 protein Vpr has inhibitory effect on Integrase activity. The inhibition is a result of protein-protein interactions. Specifically Vpr interacts through its C- terminal domain. Results from previous studies indicate that the active petptide inhibition motif is peptide 1 (Figure 1). Figure 1. Amino acid sequences of peptides 1 and 2, and outline of the study. Regarding the SAR studies, E-K pairs were introduced in i and i + 4 positions to increase the helicity, by forming salt bridges. In the same study to peptide 1 was added an octa-arginine tail, the purpose of which was to improve, cell permeability. The presence of the octa-arginine tail however resulted in increase of cytotoxicity of the peptide. The hypothesis on which the current study was based is that by finding a different way to improve cell permeability without the 8-R tail the cytotoxicity of the peptide would decrease. The idea was to make the peptide more lipophilic, by adding hydrophobic groups on the external of the a-helix, and at the same time improve its helicity. An available method to achieve that is the use of a-helix stabilized peptidomimetics. Specifically, hydrocarbon stapled peptides, in which a hydrocarbon link is formed between successive turns, via a ring closed metathesis (RCM) reaction, were used. By having a hydrocarbon linkage between positions i and i+4 in the a-helix, the helicity is improved because the two positions are covalently bound via the hydrocarbon chain, and simultaneously the lipophilicity and cell permeability of the peptide is increased because of the presence of a hydrophobic hydrocarbon chain on the external part of the a helical structure. In Figure 1 is presented an outline of the study. Design and synthesis of the peptides The lead peptide sequence used was sequence 1 (Fig.1). From previous studies it was known that residues: Phe12, Ile13, Phe15, and Ile17 are vital for IN inhibition activity. Stapling was performed between i and i+4 positions by avoiding substitution of these residues. Protected linear peptides were constructed by Fmoc-solid phase peptide synthesis. The RCM reactions of the protected linear peptides were performed on the resin by treatment with ruthenium-mediated Grubbs second catalyst in 1,2-dichloroethane. All hydrocarbon and all ether stapling was performed, however the first technique resulted in higher yields as it’s presented in Table 1. After RCM, the peptides were deprotected, acetylated, and cleaved from the resin. Purification of the stapled peptides was done by HPLC. However it is not the purpose of this paper to present experimental details. Table 1. Sequences of Designed Stapled Peptides and Their Conversion Yields of RCM Reactions CD Spectroscopy of Linear and Stapled Peptides. CD Spectroscopy was used to analyze the secondary structures of the synthetic stapled peptides, 3S−9S and 11S. Linear peptides, 4L−6L, 8L, 9L, and 11L, were used as control (Figure 3). Negative peaks at 208 and 222 nm, are characteristic for ÃŽ ±-helical structures. All stapled peptides, except 3S, formed ÃŽ ±-helices. The corresponding linear peptides on the other hand including compound 1 showed a broad negative peak around 215 nm, which indicates a ÃŽ ²-sheet structure. It is obvious that stapling of the linear peptides leads to the formation of ÃŽ ±-helices. Figure 3. CD Spectra of stapled peptides (left) and corresponding linear (right). Integrase (IN) Inhibition Assays and MT-4 Luc Assays (anti HIV). The next step was to determine the potency of the synthesized peptides using integrase inhibition assays. IC50 values were determined for stapled and linear compounds regarding both 3-end processing and strand transferring reactions (Figure 4 Left). Anti HIV activity was also screened for all peptides using MT-4 Luc Assays (Figure 4 Right). Figure 4. IC50 Values (Left). MT-4 Luc Assay (Right) All compounds had integrase inhibition activity, however lead compound 2 was way more potent. Regarding the MT-4 Luc assays compound 6S showed similar anti HIV activity as lead compound 2 at concentrations higher than 2.5 um. Compound 8S also showed significant activity at concentrations higher than 5 um. 6S and 2 have almost the same level of anti-HIV activity in cells, however 2 has much higher IN inhibitory activity in vitro than compound 6S. Imaging Experiments Stapled and linear peptides were labeled with fluorescein and imaging experiments were performed to examine their cell permeability. The stapled peptides 6S and 8S demonstrated improved cell permeability compared to the lead compound and the linear peptides. Octaarginine tail functional role investigation. The next step was to study the functional role of the (Arg) 8 tail, besides influencing cell permeability. By using 6S and 6L as lead compounds, a new set of peptides was synthesized (Figure 5). Specifically conjugates of 6S with octaarginine (17) and with the quartet repeat of arginine and glutamic acid (18). For 6L, with the quartet repeat of arginine and glutamic acid (19), and the conjugates of 6S with tetra-arginine (20), penta-arginine (21), hexa-arginine (22), and hepta-arginine (23). IC50 values were determined for the new set of peptides and also MT-4 Luc assays were performed. The presence of the octaarginine tail is necessary for the inhibitory activity however it still makes the peptides cytotoxic. Different lengths in the Arg tail were also examined. Still the octaarginine (17) conjugated peptide is the most potent but compounds 22 and 23 had good potency and lower cytotoxicity than 17, so those compounds were selected as lead compounds for further development. DNA binding experiments were also performed to examine the role of Arg8 tail, and the results indicate that 17 has high DNA binding affinity and that might influence the high inhibition activity of the peptide. Conclusions and Critical Review Stapling caused a significant increase in ÃŽ ±-helicity and cell membrane penetration, and in the expression of potent anti-HIV activity in cells. Stapling and the addition of octa-arginine caused cell membrane penetration. Stapling by itself did not involve cytotoxicity while incorporation of octa-arginine into the structures increased the cytotoxicity of the compounds. Generally it was a well-organized paper. It had good flow of information and background information was provided. The hypotheses were not stated but were easy to understand. The experiments and the data supported the conclusions and the concepts. The figures and the graphs were interpretable and accurate in supporting the conclusions related to them. However there are several interesting points to be addressed. The first point is the configuration of the new double bond formed. It would be interesting to see if the configuration of the double bond would affect the secondary structure and the helicity of the peptides. Another question that need to be addressed is why the stapled peptide 3S did fold into b sheet structure unlike the other stapled peptides which formed a helices. It would be interesting to examine the role of the substituted amino acids of 3S, in the folding of the peptide. Regarding the role of the octaarginine tail, the DNA binding experiments indicate that the octaarginine conjugated peptide has affinity for DNA binding. However it is unclear how exactly the tail affects the potency and the cytotoxicity. Further experiments are necessary to clarify that. I would suggest some NMR experiments to investigate the binding. First 1H-15N HSQC may be performed to the (Arg)8 fused peptide before and after binding with DNA. That would show which residues are involved in binding and would give data to determine the specific interaction. References: Nomura, Wataru, et al. Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products. ACS chemical biology 8.10 (2013): 2235-2244.

Monday, January 20, 2020

Health Insurance Portability and Accountability Act Essay -- Healthcar

The Standards for Privacy of Individually Identifiable Health Information, better known as the Privacy Rule, that took effect in April 2003 for large entities and a year later for small ones, was established as the first set of national standards for the protection of health information. This rule was issued by the U.S. Department of Health and Human Services to meet the requirement of the Health Insurance Portability and Accountability Act of 1996 (HIPAA). The Privacy Rule was born out of a need for health information to be appropriately protected yet still allowing the health information to be shared to ensure quality health care and to protect the public’s health and well being. It allows for the protection of the privacy of the patient and yet it also permits vital uses of information. The Privacy Rule established a category of health information that a covered entity may only use or disclose to others in certain circumstances and under certain conditions. According to the National Institute of Health Publication Number 03-5388, the protected information is known as Protected Health Information (PHI) and includes individually identifiable health information transmitted by electronic media, maintained in electronic media, or transmitted or maintained in any other form or medium. However, it excludes education records covered by the Family Educational Rights and Privacy Act, as amended, 20 U.S.C. 1232g, records described at 20 U.S.C. 1232g(a)(4)(B)(iv), and employment records held by a covered entity in its role as employer. Covered entities are organizations that are subject to the Privacy Rule. Three types of covered entities are 1) Health Plans - which are individual or group plans that provide or pay the cost of medi... ... and HIPAA, Does instant access and availability from mobile technology jeopardize patient privacy? [Electronic version] Nursing Management, June 2007, 38-40 Martin, J. (2008). Who’s looking at your medical records? COPDConnection.com Retrieved November 12, 2011, from http://www.healthcentral.com/copd/c/19257/30481/comments Robertson, L. (2008). Who’s looking at your medical records? [Electronic version] Saturday Evening Post, 280.3, 54-92, Consumer Health Complete. Protecting Personal Health Information in Research: Understanding the HIPAA Privacy Rule, NIH Publication Number 03-5388. Retrieved November 12, 2011 from http://privacyruleandresearch.nih.gov/pr_02.asp Summary of the HIPAA Privacy Rule, Office of Civil Rights Privacy Rule Summary, (2003). Retrieved November 12, 2011 from http://www.hhs.gov/ocr/privacy/hipaa/understanding/summary/privacysummary.pdf

Sunday, January 12, 2020

Word Narrative

Collaborative practice I've been in hospital a few days now. I've settled in. Well as much as you can be expected to when you're in a strange environment. The first day was awful for me though, I had no idea what was going on. I'd just started my 3 weeks annual leave (l work abroad so I was looking forward to spending time with my family etc. ) and I started having severe chest pains at home. They were crushing pains I can't explain the pain in any other way than it felt like a vice. My wife called 999 and the ambulance asked a lot of questions, before I knew t I was on my way to hospital.I remember everyone just running around, it felt like no one was actually talking to me. Like I was invisible! The doctors were saying something about a possible stroke, but not to me, they were talking amongst themselves. They attached a load of wires to me and the monitor they attached me to constantly beeping. Still drives me crazy that noise all around the ward. Some of the nurses are nice, not all of them seem to like me though. Maybe I'm an inconvenience? Hope they don't think that. I know they are all really busy, that's obvious.I finally found out that have suffered a stroke and I need to stay in the hospital until I'm well enough to go home. Although most of what they said to me was not in a language I could understand! I can remember asking where my wife was a lot and no one answering me, which was really frustrating as I knew she would be equally as worried. Didn't get told when would be able to see her for at least an hour after arriving at the hospital. The ward I'm on has really strict visiting hours so my wife can only visit me for two hours a day and she isn't allowed to bring he children which is a shame.But have been told I will probably only spend 5 days on this ward and that if I'm not ready to go home I will be moved on to a ward with more flexible visiting hours. I'm looking forward to that. The thing that hate the most about being on a ward is having to use a commode behind a curtain. I am a 41 year old man and to be honest I find it very embarrassing and undignified. I'm not saying my experience her has been completely unpleasant but the sooner I get out of here the better and I will be in no hurry to come back.

Friday, January 3, 2020

Rape Trauma Syndrome Essays - 1705 Words

You can most commonly find dictionaries defining rape as a sexual act committed by force especially on a woman (American Heritage). Until a few years ago it was limited to penile penetration of the vagina. Penal Code two hundred sixty-one defines rape as an act of sexual intercourse accomplished with a person who is not the spouse of the perpetrator without the lawful consent (Roberson). Penal Code two hundred sixty-three goes on to say that the fundamental wrong at which the law of rape is aimed is . . . the violation of a womans will and sexuality (Roberson). All other sexual assaults are categorized under different names, yet the result is most often the same. To most Americans Rape has a tendency to be one of the cruelest†¦show more content†¦These are devastating losses. Thus, many survivors report that the offender irrevocably changed their lives. The offender steals a part of the victim that can never be returned. We can examine the impact of rape in various ways. One perspective takes into consideration the underlying meaning the assault has for the victim. The grave threats and incredible losses the victim suffers alters their life dramatically, sometimes forever. Another manifestation of the impact of rape is the anguish of the victims. The psychological and behavioral symptoms of distress are poignant symbols of the destructiveness of the offender’s acts. Yet another way to understand the impact of rape is to compare it with other forms of trauma. Rape is an extreme form of human cruelty that in some ways mirrors other overwhelming traumatic events. Rape Trauma Syndrome is the acute phase and long-term reorganization process that happens because of forcible rape or attempted forcible rape (American Journal). Researchers have discovered stages that the victim goes through while suffering the effects of victimization (Parad). The first impact of rape is a feeling of numbness; the victim is in a state of shock and disbelief and still may be in terror (American Journal). The victims appearance can be misleading, appearing jolted or astonished, sedate and stifled (Parad). The controlled behavior covers up the serious psychological wound they are suffering from (Parad). Expressions of disbelief are mostShow MoreRelatedEssay about Psychological Effects of Sexual Assault1504 Words   |  7 Pagesinterchangeably with the word rape. The decision on whether or not to use the term rape or sexual assault is made by a state’s jurisdiction. Sexual assault is more readily used in an attempt to be more gender neutral (National Victim Center). Sexual assault can be most easily described as forced or unconsentual sexual intercourse. The individual that is performing these acts on the victim may ei ther be a stranger or an acquaintance. In 1994, 64.2 percent of all rapes were committed by someone theRead MoreExamining Effectiveness Of Treatment Strategies Used With Survivors Of Rape1357 Words   |  6 PagesTreatment Strategies Used With Survivors of Rape Therapy for survivors of rape is often difficult to obtain. The lack of availability of counselors who specialize in specific trauma treatments, like prolonged exposure and cognitive-processing therapy, as well as lack of insurance and location, are hardships for treatment-seeking individuals. Therefore, it is important to pinpoint the most effective treatments for those who have suffered the trauma of rape. The purpose of this research is to outlineRead MoreRape, Being A Touchy Subject1348 Words   |  6 PagesRape, being a touchy subject for most, is definitely something that should be addressed and tackled. There is no and should never be any excuse for rape. â€Å"No† means â€Å"No†. Everyone is entitled to make that choice- it should never be made for them. 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When a woman gets raped, she experiences Rape Trauma Syndrome (a medical term given to the response that survivors of rape). If the incident caused the woman to get pregnant, there is a high possibility that she might want to get an abortion. Sam Sherwin writes â€Å"If the fetus is the result of rape or incest, then the psychological pain of carrying it may be unbearableRead MoreHuman Trafficking Is A Problem Within The U.s. Essay1617 Words   |  7 Pageslocal law enforcement officials. Raids as an anti-sex trafficking measure severely impact sex trafficked victims. Because of their complicated legal status and their language barriers, the arrest or fear of arrest creates stress and other emotional trauma for trafficking victims. Victims may also experience physical violence from law enforcement during raids. Trafficking victims are also exposed to different psychological stressors. They suffer social alienation in the host and home countries. StigmatizationRead MoreThe Effects Of Sexual Assault And Rape On The Mind, Body, And Spirit1393 Words   |  6 PagesThere are many short and long term effects of sexual assault and rape that affect the mind, body, and spirit. Many survivors experience one or more of these eff ects and they are not mutually exclusive. Many people who go through traumatic events may find thats it can take some time to re-adjust and cope for a period of time after the event. The residual mental, physical and spiritual effect of sexual assault and rape can permeate the daily lives of survivors,which makes it difficult to heal. ForRead MoreEssay on Sexual Abuse on Women1250 Words   |  5 PagesSexual abuse, also known as sexual assault, is any sort of sexual activity that one doesn’t agree to which includes, inappropriate touching, vaginal, anal, or oral penetration, sexual intercourse that one says no to, rape, attempted rape, as well as child molestation. Sexual abuse is usually verbal or visual. It can also be anything that forces a person to be in unwanted sexual contact. There are many examples of sexual abuse like voyeurism, exhibitionism, incest, and sexual harassment. Voyeurism